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Mission StatementDiapharma Group, Inc. in West Chester, Ohio sells hemostasis, thrombosis, platelet function testing, instrumentation, and apoptosis products in the diagnostic and research fields and provides strong technical competence and experienc...
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Diapharma/Rox Factor XIa/110050/Kit/2x50 tests

Diapharma/Rox Factor XIa/110050/Kit/2x50 tests
  • Diapharma/Rox Factor XIa/110050/Kit/2x50 tests
商品介绍

Description:

RoxFactorXIaisachromogenicassaykitbaseduponFXagenerationforquantitativeactivitydeterminationofFactorXIainenrichedorhighlypurifiedproteinpreparations.Notintendedforanalysisofplasma.

  • DetectionLimit=about0.03mU/mL
  • Nouseofhumanplasma

Rossix Rox Factor XIa chromogenic assay kit

MeasurementPrinciple:

HumanFXIaisdeterminedfromitsactivationofhumanFactorIXandensuingactivationofhumanFactorX.GeneratedFactorXaisthenmeasuredwithachromogenicFXasubstrate.

TheactivationofFactorIXisperformedintwosteps:

  1. InitialactivationofFIXintheabsenceofphospholipids.
  2. ContinuedactivationofFIXinthepresenceofFXandphospholipids,therewithallowingconcomitantactivationofFX.

Rossix Rox Factor XIa chromogenic assay kit measurement principle

Typicaldose-responsecurves:

110050_Rox_Factor_XIa_Curve_64

110050_Rox_Factor_XIa_Curve_64_2

Background:

FactorXI(FXI)hasbeenidentifiedasariskfactorforbotharterialandvenousthromboembolism(Ref1-3).PlasmafractionationproceduresmaysometimesbeassociatedwithinadvertentactivationofhemostasiszymogenproteinssuchasFXIandFactorXIa(FXIa)canbeacontaminantinintermediateorfinalproductssuchasimmunoglobulins(IgG).ThromboemboliceventshavebeenreportedtooccurafterintravenousadmiNISTrationofIgGandensuingdetailedanalysesappearedtolinktheseeventstothepresenceofFXIaintheadministeredIgGbatches(4-7).RoutinetestssuchastheNAPTTmaynotbesufficientlysensitivetodetectrelevantlowlevelsofFXIa,possIBLypartlyexplainedbymatrixinterference.RoxFactorXIaoffersahighlysensitivechromogenicmethodfordeterminationofsub-picomolarlevelsofFXIa,therewithallowinghighsampledilutionsandminimizinginterferencefromthesamplematrixandfromcontaminatingproteinssuchaskallikrein,zymogenFXIandFIXa.

  1. MeijersJCM,TekelenburgWLH,BoumaBN,BertinaRM,RosendaalFR.
    HighlevelsofcoagulationfactorXIasariskfactorforvenousthrombosis.
    NEnglJMed342,696-701(2000).
  2. DoggenCJM,RosendaalFR,MeijersJCM.
    Levelsofintrinsiccoagulationfactorsandtheriskofmyocardialinfarctionamongmen:OppositeandsynergisticeffectsoffactorsXIandXII.
    Blood108,4045-4051(2006).
  3. SuriMFK,YamagishiK,AleksicN,HannanPJ,FolsomAR.
    Novelhemostaticfactorlevelsandriskofischemicstroke:theAtherosclerosisRiskinCommunities(ARIC)Study.
    CerebrovascDis29,497-502(2010).
  4. WoodruffRK,GriggAP,FirkinFC,SmithIL.
    Fatalthromboticeventsduringtreatmentofautoimmmunethrombocytopeniawithintravousimmunoglobulininelderlypatients.
    Lancet2,217-218(1986).
  5. CaressJB,Hobson-WebbL,PassmoreLV.
    Case-controlstudyofthromboemboliceventsassociatedwithIVimmunoglobulin.
    JNeurol256,339-342(2009).
  6. FosterR,SuriA,FilateW,etal.
    UseofintravenousimmuneglobulinintheICU:aretrospectivereviewofprescribingpracticesandpatientoutcomes.
    TransfusMed20,403-408(2010).
  7. EtscheidM,Breitner-RuddockS,GrossS,HunfeldA,SeitzR,DodtJ.
    IdentificationofkallikreinandFXIaasimpuritiesintherapeuticimmunoglobulins:implicationsforthesafetyandcontrolofintravenousbloodproducts.
    VoxSanguinis102,40-46(2012).
  8. LindquistPA,FujikawaK,DavieEW.
    ActivationofbovineFactorIX(ChristmasFactor)byFactorXIa(ActivatedPlasmaThromboplastinAntecedent)andaproteasefromRussell´sViperVenom.
    JBiolChem253,1902-1909(1978).
  9. WalshPN,BradfordH,SinhaD,PipernoJR,TuszynskiGP.
    KineticsoftheFactorXIacatalyzedactivationofhumanbloodcoagulationFactorIX.
    JClinInvest73,1392-1399(1984).
  10. TansG,Janssen-ClaessenT,vanDieijenG,HemkerHC,RosingJ.
    ActivationofFactorIXbyFactorXIa–aspectrophotometricassayforFactorIXinhumanplasma.
    ThrombHaemost48,127-132(1982).
品牌介绍

Mission Statement

Diapharma Group, Inc. in West Chester, Ohio sells hemostasis, thrombosis, platelet function testing, instrumentation, and apoptosis products in the diagnostic and research fields and provides strong technical competence and experience to ensure customer expectations will be met or exceeded.

diapharma hemostasis chromogenic clotting elisa assay test kit

 

History

The Diapharma Group, Inc. formed on January 1, 1997 from Pharmacia Hepar, Inc. in Franklin, Ohio, and began as the exclusive US and Canadian distributor of the Chromogenix substrates and assays.

Over a quarter-century ago, Chromogenix developed the first chromogenic substrate technology under the former name, Kabi Diagnostica. Kabi later merged with Pharmacia. Some of Diapharma’s current staff worked inside the Chromogenix department within Pharmacia’s heparin manufacturing plant.

In 1998, Diapharma moved to West Chester, Ohio, where it remains today. Over the years, Diapharma expanded its product line to include a variety of hemostasis, cell death, platelet function, ecotoxicology, assays, reagents, antibodies and instruments from superior manufacturers.

In 2017, Diapharma celebrated twenty years of success



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