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Diapharma/TECO® Urinary Collagen IV/TE1054/Kit/96 tests

  • 产品编号: TE1054
  • 美  元  价: $0.00
  • 会  员  价: 待定
  • 品       牌: Diapharma
  • 产       地: 美国
  • 公       司: Diapharma Group, Inc.
  • 产品分类: ref="." class="index">首页 > Diapharma/TECO® Urinary Collagen IV/TE1054/Kit/96 tests
  • 公司分类: Liver & Kidney Biomarkers
:Kit/96 tests
Diapharma/TECO® Urinary Collagen IV/TE1054/Kit/96 tests
  • Diapharma/TECO® Urinary Collagen IV/TE1054/Kit/96 tests
商品介绍

Description:

The TECO®Urinary Collagen IV ELISA provides a method for the quantitative determination of collagen IV in human urine.

Kit Composition:

  • Collagen IV Antibody coated Microassay Plate 12 strips of 8 wells (96 beak apart wells in total), in a frame. Ready to Use
  • Collagen IV Calibrator—Standard A Ready to Use, 0.8 ug/L
  • Collagen IV Calibrator—Standard B Ready to Use, 3.2 ug/L
  • Collagen IV Calibrator—Standard C Ready to Use, 12.5 ug/L
  • Collagen IV Calibrator—Standard D Ready to Use, 50 ug/L
  • 10X Wash Buffer Concentrate
  • Assay Buffer Ready to Use
  • Enzyme Conjugate Anti-collagen IF mouse Fab’ conjugated to HRP. Ready to Use
  • TMB Substrate Ready to Use
  • Stop Solution 1M Sulphuric Acid, Ready to Use
  • Plate Seal

Assay Principle:

The TECO® Urinary Collagen IV ELISA is designed for the assay of urinary collagen IV. It is a solid phase one-step sandwich ELISA. Collagen IV in the sample is bound simultaneously by a solid phase monoclonal antibody and a monoclonal antibody-enzyme conjugate directed at different antigenic sites. This results in the collagen IV molecule being sandwiched between the solid phase and enzyme labelled antibodies. After removing unbound enzyme labelled antibody and sample, the plate is then incubated with enzyme substrate, resulting in the development of a color. The color developed is directly proportional to the amount of collagen IV in the sample.

Typical Calibration Curve

Typical calibration curve obtained using Serum Collagen IV ELISA. 4-Parameter plot of A450/630 nm versus ug/L Collagen IV. Assay range is 0.8-50 ug/L Collagen IV.

Background:

Collagen IV is a type of non-helical forming collagen found primarily is the basal lamina (basement membrane), and it is considered to constitute its basic framework. Urinary collagen IV levels are elevated in a variety of renal pathologies, particularly diabetic nephropathy. Urinary collagen IV is significantly higher in patients with non-insulin dependent diabetic mellitus (NIDDM) than in normal subjects and urinary collagen IV levels correlate with the deposition of collagen IV in the kidney. In diabetic subjects, urinary collagen IV is significantly increased in patients with microalbuminuria or overt proteinuria as compared to those with normoalbuminuria. Moreover, in diabetics with normoalbuminuria, those with elevated urinary collagen IV were at an increased risk for progression to microalbuminuria. Intensive therapy of diabetic nephropathy can slow the temporal increase in urinary collagen IV in diabetics indicating the potential of urinary collagen IV for studying the renal effects of new therapies. These results suggest that the measurement of Urinary Collagen IV might provide a useful bioMarker for studying diabetic nephropathy.

In the field of renal transplantation, renal collagen IV levels are increased and increased urinary collagen IV levels are found in acute renal rejection, indicating the potential value of urinary collagen IV in studying these conditions.

品牌介绍

Mission Statement

Diapharma Group, Inc. in West Chester, Ohio sells hemostasis, thrombosis, platelet function testing, instrumentation, and apoptosis products in the diagnostic and research fields and provides strong technical competence and experience to ensure customer expectations will be met or exceeded.

diapharma hemostasis chromogenic clotting elisa assay test kit

 

History

The Diapharma Group, Inc. formed on January 1, 1997 from Pharmacia Hepar, Inc. in Franklin, Ohio, and began as the exclusive US and Canadian distributor of the Chromogenix substrates and assays.

Over a quarter-century ago, Chromogenix developed the first chromogenic substrate technology under the former name, Kabi Diagnostica. Kabi later merged with Pharmacia. Some of Diapharma’s current staff worked inside the Chromogenix department within Pharmacia’s heparin manufacturing plant.

In 1998, Diapharma moved to West Chester, Ohio, where it remains today. Over the years, Diapharma expanded its product line to include a variety of hemostasis, cell death, platelet function, ecotoxicology, assays, reagents, antibodies and instruments from superior manufacturers.

In 2017, Diapharma celebrated twenty years of success


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